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Neurotransmitters released at synapses activate neighboring astrocytes, which in turn, modulate neuronal activity by the release of diverse neuroactive substances that include classical neurotransmitters such as glutamate, GABA or ATP.
Neuropeptides released from dense-core vesicles (DCVs) modulate neuronal activity, but the molecules driving DCV secretion in mammalian neurons are largely unknown.
Because of their slow activation and their lack of inactivation, M-channels could modulate neuronal activity during repetitive spike discharge and tune neurotransmitter release.
The application of UCNPs has recently been extended to optogenetically modulate neuronal activity using near-infrared light.
Unlike its predecessors, which use static thresholds to modulate neuronal activity, the BCM learning rule allows the threshold to be dynamic.
All neurons express PDEs, and PDE inhibition represents a mechanism through which it could be possible to precisely modulate neuronal activity.
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Electrical microstimulation of FEF (FEF-EM) modulates neuronal activity in area V4 (Moore and Armstrong, 2003) and elicits functional magnetic resonance imaging (fMRI) activations in visual cortex in a bottom-up dependent manner (Ekstrom et al., 2008).
Caffeine also modulates neuronal activity [18].
These studies revealed important functions of muscarinic receptors modulating neuronal activity and neurotransmitter release in many brain regions, shaping neuronal plasticity, and affecting functions ranging from motor and sensory function to cognitive processes.
Several investigations have demonstrated however that US modulates neuronal activity by enhancing and/or suppressing the amplitudes and/or conduction velocities of evoked nerve potentials [3], [4], [18] [24].
Consequently, PET-fMRI studies make it possible to evaluate the hypothesis that DA neurotransmission can change regional blood oxygenation level dependent (BOLD) signals by modulating neuronal activity [4].
More suggestions(15)
modulate neuronal metabolism
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modulate neuronal sodium
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modulate enzyme activity
modulate neuronal growth
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modulate mTOR activity
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modulate neuronal hyperexcitability
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