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While the ability of OxPL to modulate biological processes is increasingly recognized, the nature of the biologically active OxPL species and the molecular mechanisms underlying their signaling remain largely unknown.
Understanding how the cells modulate biological processes to accommodate the adverse effects of mtDNA dysfunction is important as it may provide vital clues in the search for modifier genes as well as therapeutic targets.
ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation.
Therefore, effects of VPA on the degree of Erk1/2 phosphorylation and HDAC inhibition seem to be independent responses that, subsequently, may modulate biological processes such as cell growth or motility through independent mechanisms.
The development of new approaches to small-molecule library screening enables opportunity for compound discovery to target pharmacologically intractable proteins, such as transcription factors, and to modulate biological processes in the absence of knowledge of the target critical to the state switch.
Because SUMO is known to modulate biological processes by providing a binding surface for proteins that have the ability to bind to it, we considered the possibility that our ChIP results could be explained by a role of SUMO in enhancing a direct interaction between Tpz1 and Stn1/Ten1 27.
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Post-translational modifications are known to influence protein characteristics such as protein folding and stability, thus modulating biological processes like cell growth and migration [ 11].
It is highly conserved among eukaryotic species, including protists, fungi, plants and animals, and plays a fundamental role in modulating biological processes, particularly the regulation of transcription (Jaenisch and Bird 2003; Patra et al. 2008; Chen and Riggs 2011; He et al. 2011).
Natural ligands and receptors, which inherently modulate complex biological processes, have emerged as promising candidates for protein-based drug discovery efforts.
Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis.
Posttranslational protein modifications are known to modulate key biological processes like proliferation and apoptosis.
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modulate apoptotic processes
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