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EPOP interacts with the transcription elongation factor Elongin BC and the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC.
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Upon phosphorylation, many nuclear proteins, including transcription factors, bind to 14-3-3s, which contheirtheiratete of nuclear import/export thereby modulating transcriptional processes [ 52].
Thus, the post-translational modification of histones modulates not only the transcriptional processes of initiation, elongation and termination, but co-transcriptional processes as well.
NusA binds to RNA polymerase and modulates several of the ribosomal RNA transcriptional processes.
The transcription factors (TFs) are important regulators that modulate transcriptional program, which is one of the most important biological processes.
To do this we use the mouse as a genetic model system and interrogate both extrinsic signaling pathways that modulate their differentiation as well as key intrinsic transcriptional processes.
Kriebs, A. et al. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Transcription factors are nuclear proteins recognizing specific DNA sequences in gene promoters that modulate transcriptional activity in response to extracellular stimuli.
Future studies may explore whether such lipids modulate transcriptional regulators in other contexts and whether there are more examples of such lipid-mediated signaling mechanisms that shuttle between the cytoplasm to regulate the nucleus function of transcriptional factors.
Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency.
These latter factors modify histones and interact with the basal transcriptional machinery to modulate transcriptional initiation [1].
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