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However, additional studies, including genome-wide analyses, have revealed that E2F factors modulate a plethora of cellular functions, including DNA replication and repair, apoptosis, signal transduction, and metabolism [1], [2].

Citral's primary potency on TRPM8 may explain its initial 'cool' sensation, and citral may modulate a plethora of skin, nerve, and epithelial cell-mediated sensory responses via the TRPV2, TRPV3, TRPV4, and TRPA1 channels.

Estrogens have important antioxidant properties, but estrogen signaling is complex and intricate, and estrogens can modulate a plethora of signaling pathways that are often cell or tissue-specific.

In PCa cells green tea catechins, and especially EGCG, are able to modulate a plethora of cell signaling pathways crucial for cancer cell transformation and survival [ 97, 100– 102].

Due to this post-translational modification, the role of numerous proteins is controlled by proteases, which then modulate a plethora of cellular mechanisms, such as cell growth, apoptosis, protein secretion, phagocytosis, signal transduction and extracellular matrix turnover (Puente et al, 2005).

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Transcriptionally active β-catenin therefore modulates a plethora of downstream biological processes, including pluripotency, EMT, oxidative stress and lineage commitment.

The intestinal microbial landscape is modulated by a plethora of host-extrinsic and host-intrinsic factors.

G protein-coupled receptors (GPCRs) are the largest family of cell signaling transmembrane proteins that can be modulated by a plethora of chemical compounds.

The cytochrome P450 enzyme CYP1A2 plays a main role in the metabolism of a variety of structurally unrelated compounds, including a broad range of different drugs, and its activity is widely modulated by a plethora of inducer/inhibitor molecules.

One of the hallmarks of regulatory cells is their remarkable plasticity as they can be positively or negatively modulated by a plethora of cytokines, growth factors and co-stimulatory signals that tailor their differentiation, stability and survival.

Autophagy, a highly conserved homeostatic mechanism for the degradation and recycling of bulk cytoplasm, long-lived proteins and organelles [ 1], is triggered and modulated by a plethora of different stimuli such as nutrient deprivation and other stress signals.

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