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Dr Tuomas Knowles, says: "There are no disease modifying therapies for Alzheimer's and dementia at the moment, only limited treatment for symptoms.
This paper discusses the use of machine learning techniques for the classification of medical data, specifically for guiding disease modifying therapies for Sickle Cell.
Current FDA approved disease modifying therapies for MS such as beta interferon, glatiramer acetate and natalizumab are only partially effective and cause side-effects.
Disease modifying therapies for Alzheimer's disease (AD) are based on strategic approaches towards the "amyloid cascade hypothesis" [ 1].
There are currently no effective disease modifying therapies for ALS and 70%% of those affected die within three years from symptom onset [ 2].
More definitive elucidation of the mechanism(s) that underlie induction and spread of αS pathology are likely to provide key insights into ongoing efforts designed to target αS in vivo and thereby ultimately lead to novel disease modifying therapies for PD and other α-synucleinopathies.
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Hydroxychloroquine (HCQ) is a common disease modifying therapy for the treatment of rheumatoid arthritis (RA).
The concept of "learning health systems" has therefore been proposed [ 113], in which high-quality patient care is combined with routine data collection, without systematically modifying therapy for the purpose of developing generalisable knowledge [ 113].
This has important implications for targeting future disease modifying therapies and, more immediately, for counselling of patients and family members.
Currently, there is no disease modifying therapy available for OA.
Because A βO immunotherapy is promising for preemptive disease modifying therapy, research aimed at elucidating the molecular mechanisms underlying the action of A βOs and/or antibodies targeting A βOs is clearly required.
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