Sentence examples for modifying complex from inspiring English sources

For example, the jumonji protein (JARID2) was found to form a chromatin modifying complex that methylates H3K9 at the cyclin D1 promoter by recruiting G9a and GLP, two histone methyltransferases [51].

The integrative approach using random small RNA libraries and cell-based genetic selection provides a novel technology platform for identifying RNA effectors capable of modifying complex cellular phenotypes through control of the expression level of multiple targets.

Here, we report on the development and application of a convergent random small RNA expression library for use in mammalian cell types to isolate novel RNAs capable of modifying complex cellular phenotypes.

The advantages associated with using a convergent promoter format for producing random RNAi libraries are the potential for producing small RNAs that operate by canonical and non-conventional mechanisms to control single or multiple target genes and the possibility of discovering novel, multifunctional small RNAs capable of modifying complex cellular phenotypes.

ARP6 is a component of chromatin modifying complex implicated in maintaining state of gene activation [ 66].

The molecular mechanisms underlying SChLAP1's oncogenic function were also connected to a chromatin modifying complex, namely SWI/SNF.

They also actively regulate chromatin remodeling via histone modifying complexes, such as MYS3 and SET [19].

These associations point toward select chromatin modifying complexes and enzymes as likely epigenetic drivers of EMT.

These proteins act as histone chaperones and associate with additional chromatin modifying complexes including SIN3A, PRC2 and NURF [ 40– 40].

Unsurprisingly, SWR-C has been functionally linked to other chromatin modifying complexes including the NuA4 histone acetyltransfersase and the Ino80-C chromatin remodeling complexes [ 41].

To mimic the in vivo situation, we aimed to recruit chromatin modifying complexes to in vitro reconstituted immobilized nucleosomal templates in a competitive setting.