Sentence examples for modifications that lead from inspiring English sources

Examples of biochemical modifications that lead to resistance include the production of enzymes that inactivate the drug; the alteration of the protein, enzyme, or receptor targeted by the drug; the activation of drug efflux pumps that deliberately remove the drug from the cell; and the alteration of cell-wall proteins that inhibit drug uptake.

Cancer cells undergo an array of genetic and epigenetic modifications that lead to a phenotype characterized by high proliferation, death resistance, rapid growth and invasiveness.

In this review we describe our work on the rational design and development of new soluble, thermally stable, and highly reactive hypervalent iodine reagents based on structural modifications that lead to redirection of secondary bonding from intermolecular to intramolecular modes.

Under oxidant stress, many critical proteins regulating endothelial function undergo oxidative modifications that lead to ED. Cellular levels of glutathione (GSH), the primary reducing source in cells, can significantly regulate cell function via reversible protein thiol modification.

We accomplish this through fine-tuning experiments using a state-of-the-art CNN and via rigorous architecture analysis, we present several modifications that lead to accuracy improvements over prior art on a dataset of images from a popular social media platform.

Polycomb (PcG) and trithorax (trxG) proteins play important roles in establishing lineage-specific genetic programs through induction of chromatin modifications that lead to gene silencing or activation.

It was reported that within class E, the conserved specific N-terminal domain, initially described in tomato ERFs [ 17], is dedicated to an oxygen dependent sequence of post-translational modifications that leads to degradation of the protein under aerobic conditions.

However, the localization of 18S and 5S rDNA on the neo-X1 and neo-Y chromosomes of Dichromatos species suggests that the neo-X1X2Y sex determination systems share a common origin, but these chromosomes have also undergone distinct modifications that led to their differentiation.

Lattice flexures are a flexure modification that leads to low motion-direction bending stiffness.

Therefore, when the pump power is changed, the EDF amplification spectrum undergoes a profile modification that leads to a laser line generation in a slightly shifted wavelength.

Two analogous glycosylases, oxoguanine glycosylase (OGG) and formamidopyrimidine glycosylase (FPG), can start the process by removing oxidized guanine, the most common modification that leads to misreading of DNA.