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Various engine modifications that alter emission characteristics have been successfully introduced.
These mechanisms give rise to resistance because they result in biochemical modifications that alter certain bacterial cell properties that normally render the cell sensitive to an antibiotic.
We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development.
However, regulation of p27Kip1 protein expression and function is predominantly through post-translational modifications that alter both the cellular localization and the extent of E3 ubiquitin ligase-mediated degradation.
DNA DSBs trigger a myriad of post-translational modifications that alter catalytic activities and the specificity of protein interactions: phosphorylation, acetylation, methylation, ubiquitylation, and SUMOylation, followed by the reversal of these changes as repair is completed.
A new study reveals that homosexuality may be linked to our epigenetics, chemical modifications that alter gene activity without changing DNA sequences.
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In particular, RNA editing is an important post-transcriptional event in gene modification that alters one or more translation codons, thereby giving rise to functionally distinct proteins from a single gene [23].
In light of the findings that AR levels are similar, the androgen-independent growth component of CAsE-PE cells does not appear to be due to overexpression of a functional AR, or through an AR modification that alters steroid sensitivity or selectivity.
Methylation at specific histone lysine residues is a critical post-translational modification that alters chromatin architecture, and dysregulated lysine methylation/demethylation is associated with the silencing of tumor suppressor genes.
The specific location and type of PTMs on the DPSL protein has yet to be identified, but the change in pI suggests a modification that alters side chain charge.
It is known that epigenetic alterations, such as global hypomethylation, regional hypermethylation of tumor suppressor genes, and histone modification that alters chromatin structure, are involved in HCC.
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