Sentence examples for alterations that lead from inspiring English sources

The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV -induced genetic alterations that lead to the development of melanoma.

We propose that p53 not only limits malignant progression by suppressing the acquisition of alterations that lead to tumour progression, but also, in the context of p53 restoration, responds to increased oncogenic signalling to mediate tumour regression.

Controlled levels of ROS mediate the accumulation of (poly)phenols, and phytohormones (such as auxin) at gall sites, which contributes to the new cell developmental pathways and biochemical alterations that lead to gall formation.

The scientists will be analyzing archived blood specimens from pregnant women and neonatal blood spots from the California Department of Public Health to measure in utero chemical exposures, to profile aspects of the immune system and to identify genetic alterations that lead to leukemia.

As a consequence, the bone marrow of leukemia patients exhibits substantial alterations that lead to support of the malignant cells and to impaired hematopoiesis [42].

"We are at a stage where we are reopening two new platforms - 12 and 13 - and closing the next two - 10 and 11. "To do that we have got to have a closure while we carry out the next phase of the work and also to do the necessary track work and signalling alterations that lead up to the station".

A role for low-density lipoprotein related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass.

In contrast, MSNF9g deletes both 5'- and 3'-sequences from MSNF9, alterations that led to a loss of lamellocyte enhancer function.

This makes it reasonable to assume that the alterations that led to the resistance need to be (epi- genetically fixepi- geneticallycopy number alterations [CNAs], point-mutations, methylation).

Tumorigenesis results from a series of genomic alterations that leads to progressive disorder of the normal mechanisms controlling cell growth, death and differentiation (Bishop, 1991).

We speculate that some of these lncRNAs may be involved in structural alterations that led to their over-expression [ 2] and that some of these outlier lncRNAs may drive these tumors.