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Fibrinogen represents a potential target for oxidants, and several oxidative posttranslational modifications that influence fibrinogen structure and function have been associated with disease pathogenesis.
Well-established, rRNA undergoes extensive modifications that influence its processing, folding and functionality.
H3.3 is a carrier of various post-translational histone modifications that influence gene transcription.
Previous studies have shown that estrogen receptor alpha (ERα) can cause rapid epigenetic modifications that influence the regulation of gene expression [ 49, 50].
Signaling cascade intermediates are subject to post-translational modifications that influence target protein activity, localization, and function, such as protein phosphorylation, mediated by the opposing function of protein kinases and phosphatases (Shi 2009).
In addition to the genes that comprise its genome, the genetic make-up of an organism also includes its epigenome a collection of chemical modifications that influence whether or not a given gene is expressed as a protein.
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The most common modification that influences expression of genes is DNA methylation.
Glycosylation of proteins is a complex and versatile posttranslational modification that influences biological activity, protein conformation, stability, solubility, secretion, pharmacokinetics, and antigenicity (Dwek, 1998).
Ubiquitination is a particularly versatile post-translational modification that influences most, if not all, aspects of cellular biology [1].
Recent studies implicate the third UIM in casein kinase 2-dependent ataxin-3 phosphorylation [39], a modification that influences nucleocytoplasmic shuttling and intranuclear aggregation of ataxin-3.
It is an essential epigenetic modification that influences gene expression, X chromosome inactivation, and silencing of endogenous retroviruses.
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