Sentence examples for modifications that impact from inspiring English sources
We examined post-translational modifications that impact on microtubule stability (microtubule detyrosination and acetylation), MAP kinase signaling (ERK phosphorylation) and adhesion signals (phospho myosin light chain, phospho-FAK and tyrosine-phosphorylated proteins).
Whether partial Tip60 loss enhances Rora-mediated gene expression by relieving ATXN1-induced Rora depletion or perhaps alters specific posttranslational modifications that impact Rora-mediated transcription remains an open question.
Each entry of Epi2miR contains the detailed information about epigenetics that can regulate the expression of miRNAs, such as epigenetic modifications that impact miRNA expression, regulators that affect epigenetic modification, genes that are proven to be directly targeted by miRNAs, tissues or conditions for detection, experimental method, species and PubMed identifier (ID).
Mucin type O-glycosylation is one of the most common types of post-translational modifications that impacts stability and biological functions of many mammalian proteins.
Further studies are needed to determine whether the virus re-assortants ultimately used for egg-based A(H1N1 pdm09 vaccine manufacture possessed modifications that impacted protein structure in this region, improving antigen stability.
Collectively, our results point to α-tubulin acetylation as an important modification that impacts on kinesin vesicle dynamics, actin cytoskeletal architecture and cellular function of macrophages.
Ubiquitination is a post-translational modification that impacts almost all cellular activities, including protein degradation, cell cycle progression, apoptosis, and autophagy.
If such is the case, the entirety of the pendant group might be a substrate for further modifications that could impact the absorption and distribution of the compounds.
Thus, it seems that both circadian disruption and alcohol consumption can affect long-term changes in gene expression via epigenetic modifications that may impact a wide variety of health outcomes.
Cav3 is known to be natively palmitoylated at three positions within its C-terminal domain (C106, C116, and C129), modifications that likely impact Cav3 lipid membrane interactions, oligomerization, and function (reviewed in ref (2)).
The specific characteristics of pathological tau species that define and determine seeding capacity remain to be identified, and could be the result of a precise pattern of post-translational modifications that differentially impact conformation of the tau molecule and ultimately determine aggregate structure.
