Sentence examples for modifications represent a from inspiring English sources

In addition, numerous epigenetic modifications represent a potential goal of novel therapeutic strategies and treatment design.

Thus, balanced and proportionate modifications represent a win-win situation for everyone.

These experiments prompt questions concerning the extent to which histone modifications represent a cause or a consequence of pluripotency.

Post-translational modifications represent a vital molecular mechanism to regulate the activity of PPAR γ.

Histone amino acid modifications represent a layer of epigenetic information that is widespread in eukaryotes, including plants.

The central question raised here is whether or not bivalent domains, marked both by repressive (H3K27me3) and active (H3K4me3) histone modifications, represent a preprogrammed epigenetic signature of silent but poised chromatin or more simply reflect different degrees of silencing (H3K27me3) and transcription (H3K4me3) within a population of cells.

Therefore, reported epigenetic modifications represent an ultimate endpoint and do not reveal how silencing initiates, nor do they reveal the order of epigenetic modifications that occur during the transition from active expression to stable silencing.

This broad specificity against distinct branching modifications represents a great advantage for biotechnological processing of complex and branched polysaccharides [ 26].

Identification of specific binding proteins for all of these novel modifications represents a future research direction that is required to reveal their biological functions.

Although it may be coincidental, acetylation has recently been identified as a mechanism regulating tau turnover (32), implying that complex interplay between different post-translational modifications represents a common mechanism neurons uses to fine-tune major classes of molecular processes.

Given the identification of mutations in genes encoding proteins involved in mt-tRNA modification as a cause of mitochondrial disease (e.g., PUS1 [Bykhovskaya et al., 2004], TRMU [Zeharia et al., 2009], MTO1 [Ghezzi et al., 2012], MTFMT [Tucker et al., 2011], the disruption of these post-transcriptional modifications represents a major consideration for potential disease mechanisms.