Sentence examples for modifications constituting a from inspiring English sources

Thus, although changes to cell identity can be achieved by ectopic expression of key TFs alone, the efficiency of conversion remains painfully low, with existing chromatin modifications constituting a well-described barrier to the reprogramming process (Mikkelsen et al, 2008; Pasque et al, 2012; Chen et al, 2013b; Gaspar-Maia et al, 2013; Sridharan et al, 2013).

Our results thus suggest that epigenetic modifications constitute a primary response to elevated sleep pressure showing the potential to integrate different brain processes, and to modulate synaptic function notably by affecting the expression of synaptic elements.

Although these oxidative modifications constituted a minor fraction, compared to the NEM labeling, the precursor ion of each oxidative population was clearly identified in Figure 1B.

PCNA and its modifications constitute a molecular switch to control distinct repair pathways.

Overall, it remains to be determined whether such modifications constitute a global exosomal sorting signal in these cells.

In contrast with classifications based on the presence of PRC enzymatic subunits, mapped PRC-instigated histone modifications constitute a functional readout of PRC repression.

Regulation of repression, as surveyed by histone modifications, constitutes an important facet of SCL function at the onset of blood specification.

Epigenetic modifications, such as DNA methylation and histone modifications, constitute an additional layer regulating gene expression and thus effecting phenotypes and the development of various states of disease [ 11].

Previous 'omics' studies using long-term SWCNT exposure in vivo or in vitro models reported similar findings that protein post-translational modification constitutes a large GO signal [27,28] and is likely to play a large role in disease development and pathology.

'Interaction modification' constitutes a major pathway for NCE and includes the consequences of predator-predator interactions and the effect of predator intimidation on interspecific prey competition.

Bearing in mind the affinity of palladium for nitrogen atoms, this modification constituted a very important breakthrough, because it minimized the leaching of metallic species.