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In general the cycle modifications have a positive effect on the overall COP of the system.
Results show that the modifications have a large influence on the characteristics and carbonization behavior of the CTP.
However, modifications have a profound effect on the interaction of the PHD1 with H3 ligands, which would determine the concentrations of the PHD1 ligand required to saturate.
Our results indicated that KAM-20 and KAM-21 showed decreased glycerol production and increased ethanol production concomitant with improved fermentation properties, suggesting that these genetic modifications have a potential for improvement in the efficiency of ethanol production.
These findings reveal that subtle structural modifications have a major effect on the antibacterial activity and that it is possible to design numerous tricationic polymyxin derivatives that are antibacterial.
Structure activity relationship study shows the critical importance of the C2 modifications on the activity against MDR cancer cell line, while the C10 modifications have a rather minor effect on the potency with some exceptions.
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Glycation-induced modifications have an important impact on HSA functional properties mainly related to alteration of its conformation.
Epigenetic modifications have an important role in gene expression regulation, and malfunctioning of the regulation process can have severe consequences.
Toxins may alter target protein function by specific modifications, having a major impact on cell survival.
Interestingly, all modifications had a higher sensitivity than the WHO classification system.
It can be considered that structural modifications had a pronounced effect in the activity of the substances.
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