Sentence examples for modifications of nucleosomes from inspiring English sources

The proposed single-molecule AFM approach will be instrumental for studying the effects of various epigenetic modifications of nucleosomes, in addition to biotinylation.

The current work highlights the ability of AFM to identify structural changes in nucleosomes induced by a local modification, such as biotinylation, and thus paves the way for studies of effects of other epigenetic modifications of nucleosomes.

In vivo positioning and covalent modifications of nucleosomes play an important role in transcriptional regulation.

Eukaryotic transcription initiation is suggested to be associated with the genomic positions and modifications of nucleosomes.

Chemical modifications of nucleosomes, the complex of DNA and histone proteins that packages the eukaryotic genome, are key in the regulation of transcription, maintenance of genomic integrity, chromosome condensation and segregation [ 1].

In vivo positioning and covalent modifications of nucleosomes play an important role in epigenetic regulation, but genome-wide studies of positioned nucleosomes and their modifications in human still remain limited.

FACT is a histone chaperone that has received considerable attention for its function in facilitating RNA transcription and DNA replication by dynamically altering chromatin through modifications of nucleosome structure (Xin et al., 2009; Ransom et al., 2010).

This observation indicated that histone deacetylation results in local modifications of nucleosome organization in key regulatory elements, which seem to have a great impact on transcriptional regulation, and perhaps also on replication timing.

The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage.

Our data demonstrate that without transcription the organization and modification of nucleosomes at active loci and the local binding of specific trans-acting factors is unaltered.

This observation supports the notion that the organization and modification of nucleosomes along the DNA fiber and the binding of specific trans-acting factors, more than transcription or RNAPII-binding, determines the interaction between DNA loci and the formation of chromatin loops.