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Modifications of histones play important roles in balancing transcriptional output.
Covalent modifications of histones are inherited epigenetically across many generations.
Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones.
Posttranslational modifications of histones have developed into a burgeoning area of research yielding several approved drugs and clinical candidates.
The nervous system may include more than 100 residue-specific posttranslational modifications of histones forming the nucleosome core that are often regulated in cell-type-specific manner.
Post-translational modifications of histones serve as docking sites and signals for effector proteins and chromatin-remodeling enzymes, thereby influencing many fundamental cellular processes.
Covalent modifications of histones (acetylation, methylation, phosphorylation, ubiquitination, etc).
Several post-translational modifications of histones also occur during apoptosis.
Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription.
Covalent modifications of histones are crucial for the modulation of chromatin structure and function.
Modifications of histones are among the epigenetic marks that influence gene expression.
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