Sentence examples for modification of nucleosomes from inspiring English sources

The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage.

Our data demonstrate that without transcription the organization and modification of nucleosomes at active loci and the local binding of specific trans-acting factors is unaltered.

This observation supports the notion that the organization and modification of nucleosomes along the DNA fiber and the binding of specific trans-acting factors, more than transcription or RNAPII-binding, determines the interaction between DNA loci and the formation of chromatin loops.

Upon post-translational modification of nucleosomes, one histone copy is most likely targeted first, providing an additional level of asymmetry.

There is also evidence that chemical modification of nucleosomes, specifically hyperacetylation, can alter their biological effects in SLE.

Their participation in both TPE and PEV suggests that modification of nucleosome structure may be an early step in the process leading to the gene silencing observed in both phenomena.

The proposed single-molecule AFM approach will be instrumental for studying the effects of various epigenetic modifications of nucleosomes, in addition to biotinylation.

The current work highlights the ability of AFM to identify structural changes in nucleosomes induced by a local modification, such as biotinylation, and thus paves the way for studies of effects of other epigenetic modifications of nucleosomes.

In vivo positioning and covalent modifications of nucleosomes play an important role in transcriptional regulation.

Eukaryotic transcription initiation is suggested to be associated with the genomic positions and modifications of nucleosomes.

In vivo positioning and covalent modifications of nucleosomes play an important role in epigenetic regulation, but genome-wide studies of positioned nucleosomes and their modifications in human still remain limited.