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Chemical modifications of nanoparticles surface holds promise to confer them improved biocompatibility.
Surface modifications of nanoparticles may permit escape from the RES and prolong their circulation time in the bloodstream, while preventing damage of normal tissue.
These results demonstrated that AMP-QDs were less toxic than MPA-QDs, hinting that different surface modifications of nanoparticles will affect their cytotoxicity.
Earlier studies have investigated various surface modifications of nanoparticles with active ligands to achieve further accumulation of nanoparticles in tumor cells, which is commonly referred to as active targeting and can remarkably enhance efficiency of specific endocytosis.
Active targeting implies tailor-made surface modifications of nanoparticles with ligands that bind to specific receptors expressed on target cells.
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A role for serum albumin in surface modification of nanoparticles by poloxamine 908 is also identified.
The surface modification of nanoparticles plays a critical role to provide novel properties and functionalities for the nanoparticles.
Here we describe the development of a functional polypeptide and a simple available technology for surface modification of nanoparticles.
In particular, the preparation, characterization, and surface modification of nanoparticles, and their application in cancer therapeutics are discussed.
It has been also reported that the efficiency of arterial uptake of nanoparticles could be improved by at least sevenfold after DMAB modification of nanoparticles [29].
This technology, incorporating a functional polypeptide, may represent a completely new strategy for surface modification of nanoparticles for use in a variety of cell-associated applications.
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