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A role for serum albumin in surface modification of nanoparticles by poloxamine 908 is also identified.
The surface modification of nanoparticles plays a critical role to provide novel properties and functionalities for the nanoparticles.
Here we describe the development of a functional polypeptide and a simple available technology for surface modification of nanoparticles.
In particular, the preparation, characterization, and surface modification of nanoparticles, and their application in cancer therapeutics are discussed.
It has been also reported that the efficiency of arterial uptake of nanoparticles could be improved by at least sevenfold after DMAB modification of nanoparticles [29].
This technology, incorporating a functional polypeptide, may represent a completely new strategy for surface modification of nanoparticles for use in a variety of cell-associated applications.
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We prefer to use the term nano-bioconjugate because of the presence of biomolecules on the nanoparticle surface, which are used for further studies without any further chemical modification of nanoparticle surface.
Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes.
Moreover, modification of nanoparticle surface with covalently attached targeting ligands or by coating with certain surfactants is essential for receptor mediated uptake or adsorption of specific plasma proteins after injection in human.
Chemical modifications of nanoparticles surface holds promise to confer them improved biocompatibility.
Surface modifications of nanoparticles may permit escape from the RES and prolong their circulation time in the bloodstream, while preventing damage of normal tissue.
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