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We show using CD spectroscopy that UNA modifications can cause structural transitions in some cases although they retain the inherent G- quadruplex signature.
Errors happen on proteins including abnormally synthesized proteins, protein unfolding, abnormal cleavage, undesirable posttranslational modifications, can cause protein self-assembling into toxic oligomeric structures or aggregation into cytosolic inclusions.
Epigenetic modifications can cause the perpetuation of renal fibrosis.
Posttranslational modifications can cause a gel-shifting phenomenon (i.e., anomalous gel mobility), as observed for the phosphorylated tau protein (31 ).
Consequently, sequence modifications can cause a change in the seed region and affect the target repertoire of particular miRNA.
However, proteins are very sensitive to these conditions and slight modifications can cause protein precipitation, a loss in enzyme activity or antibody affinity.
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Similarly, price modification can cause instabilities in V2G energy trading.
Because dysregulated genome modification can cause diverse diseases, especially cancers, lncRNAs have triggered immense research interest in multiple fields.
Epigenetic changes such as DNA methylation and histone modification can cause loss or gain of gene expression, and genome-wide screens for these are being actively pursued.
A single base modification can cause replication fork collapse [4] or manifest in a mutation that disrupts the function of a gene.
However, such chemical modification processes can cause protein degradation, denaturation or loss of biological activity due to side chain disruption.
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