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The results of this work show how surface modifications can induce plastic graded properties that strengthen substrates against contact-induced damage.
Thus, genetic modifications can induce global changes in the genomic, transcriptomic, proteomic, or metabolomic profiles of the host.
These modifications can induce a loss of attenuation, so promoting the emergence of pathogenic vaccine-derived polioviruses responsible for poliomyelitis outbreaks.
It was proposed that aberrant histone modifications can induce tumor suppressor gene silencing, thereby promoting tumorigenesis.
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This modification can induce DNA mutations or alterations, which can eventually lead to diseases including cancer [ 2– 8].
Each histone modification can induce or inhibit subsequent PTMs, and such cross talk can operate on the same nucleosome or can be established between nucleosomes.
Animal models have shown that growth factors from fibroblasts can stimulate or inhibit epithelial proliferation, and that the genetic modification of fibroblasts can induce cancer [ 24, 25, 133].
These studies have shown that transplantation of gut microbiota can induce modifications in the microbiota of the receiving host, associated with either impaired or improved metabolic health, depending on the phenotype of the donor.
While these studies reveal how posttranslational modifications and allosteric effects can induce a shift in the conformational equilibrium of Cbl proteins, it is not the end of the story.
Finally, it should be noted that participants in this study had cardiovascular risk factors (overweight, arterial hypertension, diabetes, etc)., and, in this condition, the present study has shown that the fat ingested in breakfast can induce modifications on their lipid plasma profile.
Lipid electrophile modification of nucleic acids can induce base-pair substitutions, frameshift mutations, and strand breaks, whereas modification of proteins distorts tertiary structure and alters protein function.
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