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Epigenetic modifications can define how the information in genes is expressed and used by cells.
Our findings reveal an important role for a histone modification within the nucleosome core as a regulator of chromatin function and they demonstrate that lateral surface modifications can define functionally opposing chromatin states.
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Considering the new (( p,q ) )-integral given in (2.1) we can define the Kantorovich modifications of the operators (1.3) as follows.
In a similar manner, one can define associational-RR modification (see equations A5 and A6).
In this way, we can define under what conditions will happen the interaction (conformation, post-translational modification such as phosphorylated residues, sub-cellular localization etc).
Illness can define us.
Who can define David Bowie?
The courts' own judgments can define words.
Only you can define who you are.
Disease modification can be defined as treatments or interventions that affect the underlying pathophysiology of the disease and have a beneficial outcome on the course of AD.
Covalent histone modifications can alter chromatin structure and thereby define transcriptionally active or inactive chromatin states [ 29].
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