Sentence examples for modification of somatic from inspiring English sources

This led to development of viral and nonviral methods for the genetic modification of somatic cells.

Another application of CRISPR/Cas9 technology for the treatment or prevention of diseases includes the modification of somatic cells.

Nuclease-mediated genomic modification of somatic cells coupled with somatic cell nuclear transfer (SCNT) provide a new approach for creating genetically modified animal models and allow for the direct comparison of mutations in an otherwise isogenic setting.

To determine whether this hESC extract induced reprogramming was mediated by epigenetic modification of somatic cell chromatin, DNA methylation and histone acetylation levels were examined.

We propose that all of these factors interact to modulate transvection through modification of somatic chromosomal pairing.

We need to determine whether human VSELs have the same molecular signature (e.g., an open chromatin structure at the Oct4 promoter, modification of somatic imprinting, and the presence of bivalent domains) as their murine counterparts.

Role of posttranslational modification (PTM) of somatic canonical histones and histone variants is well documented and effect several chromatin-templated events.

The next stage in B cell development is antigenic contact that triggers the germinal centre reaction that includes the two additional DNA modification steps of somatic hypermutation, followed by immunoglobulin class switching.

A more promising source is induced pluripotent stem cells, which are generated by genetic modification of adult somatic cells.

Reprogramming can be promoted by pre-treatment with DNMT and HDAC inhibitors, which function through epigenetic modifications of the somatic genome and the resulting cells possess the differentiation capacity under appropriate conditions.

A previous study demonstrated that modifications of amino acids of somatic hANT proteins near a putative cardiolipin interaction site improved yeast growth in reduced oxgen conditions, and suggested that differences of lipid composition between the mitochondrial inner membranes of yeast and mammals might limit proper function [18].