Sentence examples for alteration of somatic from inspiring English sources

Though the exact etiology is unknown, the disease is believed to be due to the alteration of somatic cells during limb bud development and disturbed fetal circulation [13].

Asymmetric somatic hybridization induces high frequency of point mutations and indels, with a stronger intense than the genetic variation during allopolyplodization, which is the molecular basis of the phenotypic alteration of somatic hybrids.

API: application programming interface; CNA: copy-number alteration; Cosmic: Catalogue of Somatic Mutations in Cancer; FI: functional interactions; IGV: Integrative Genomics Viewer; TCGA: The Cancer Genome Atlas.

We verified that gastric carcinoma with alterations of EGFR (somatic mutations or copy number variation) showed a significant increase of tumour size (p = 0.0094) in comparison to wild-type EGFR carcinomas.

We have characterized genetic alterations of unknown somatic status underlying four head and neck cancer cell lines of Indian origin patient by subjecting them to a thorough karyotype based characterization, SNP array based analysis, whole exome capture sequencing, and mRNA sequencing.

In addition, a marked alteration of immune and somatic cell signaling has been implicated as an important contributor to kidney injury [ 29].

Age-related changes in the pattern of hypermutation were seen, although the analysis of variable region heavy chain (VH) genes and their lineage trees shows that an alteration in the mechanism of somatic hypermutation is unlikely.

Based on this survey of coding and noncoding sequence (at a ratio of 1 3) for 21 genes, we estimate the rate of somatic alteration could be as high as 5.3 per megabase, but this assumes that all variants are indeed somatic variants.

Using a related cloning and selection strategy in a human tumor-derived cell line, Massague and colleagues [ 14- 16] have demonstrated that distinct sub-populations of cells exist that have acquired specific gene expression patterns that predispose them to metastasize to particular organs, presumably by some form of somatic alteration.

This is probably because the detection of potential downstream relationships between pairs of driver genes relying on the mutual exclusivity of their alterations is limited by the statistical power one can achieved from the frequency of somatic alterations.

The impact of signalling-pathway alterations in RMS was recently reinforced in a genome-wide study, which characterised the profile of somatic alterations in 147 RMS tumour samples.