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Exact(8)
Fremanezumab resulted in significant reduction in the weekly number of headache days of at least moderate severity: At Week 1, (-1.1 days; p<0.0001) versus placebo (-0.5 days) At Week 2, (-1.2 days; p<0.0001) versus placebo (-0.5 days) At Week 3, (-1.2 days; p<0.0001) versus placebo (-0.6 days) At Week 4, (-1.1 days; p=0.0006) versus placebo (-0.7 days).
Of the 106 findings of hyperemic mucosa (of mostly moderate severity) at visit 1, 91 (or i.e. 85.8 %) completely resolved by visit 2. Swollen tonsils (N = 106 patients at visit 1) almost disappeared completely after 14 days of treatment with the study medication (N = 103 or i.e. 97.2 %).
However one rabbit in the conventional treated group showed moderate severity at 72 hours.
15, 41, 42, 45 Subjects (N = 537) had to have glabellar lines of at least moderate severity at maximum frown to be eligible.
BoNTA-naïve patients aged 20 64 years with glabellar lines of at least moderate severity at maximal contraction, based on standardized photography, were eligible for the study.
This multicenter, 16-week, double-blind, randomized, placebo-controlled trial compared the efficacy and safety of two doses (10 and 20 U) of BoNTA versus placebo in Japanese subjects with glabellar lines of at least moderate severity at maximal contraction.
Similar(52)
The two studies utilized similar eligibility criteria and enrolled patients who were aged 18 80 years, had diagnoses of type 1 or type 2 diabetes and MDD, and had depression symptoms of at least moderate severity, as indicated by a total score of >14 on the Beck Depression Inventory (version I) (BDI) (15).
This study enrolled male and female patients (aged 6 17 years) who satisfied Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) [ 17] criteria for a primary diagnosis of ADHD of at least moderate severity as shown by a baseline ADHD Rating Scale IV (ADHD-RS-IV) total score of 28 or higher.
Disagreement in phase 1 was greatest for videos categorised as 'normal' or 'moderate', with only 27% agreement for normal appearance and 37% for moderate severity, and at best 76% agreement for 'severe' activity.
The histopathological findings in the second subject who had undergone cholecystectomy due to size progression revealed cholecystitis of moderate severity, which, at the time of the ultrasound examination, may have been polypoid in appearance [ 27, 28].
Additionally, barring changes in application of rating criteria by new personnel and increasing direct referrals of high severity cases elsewhere, it is possible that the war resulted in an increase in common disorders with moderate severity, or at least the likelihood of seeking support for them.
Related(20)
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Justyna Jupowicz-Kozak
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