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Cytocompatibility studies on Caco-2 cells demonstrated moderate toxicity at high concentrations of the anticancer agent.
This moderate toxicity at chemical activity of unity was higher than expected relative to a reported hydrophobicity cut-off in toxicity, but lower than expected relative to a reported chemical activity range for baseline toxicity.
Indeed, with moderate toxicity at 10 μ m concentration, the oxidative phosphorylation activity can be compromised.
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TCP is shown to have moderate toxicity to salmonoids at LD50 value of 1.8 ppm (Marino et al. 1999).
27 Further, retreating patients with ipilimumab who had progressed after initially achieving disease control with ipilimumab has demonstrated some antitumor activity and clinical benefit, with only mild to moderate toxicities noted at the time of retreatment.
This was at the cost of moderate toxicity of diarrhea, nausea and fatigue [28].
Nutmeg oil had moderate toxicity and ylang ylang oil was the least toxic.
Sediment from site SLR exhibited no toxicity; samples from site C3 showed low toxicity; and sediments from sites A3, B3 and MED exhibited moderate toxicity.
The applicability of the test is limited to substances with a moderate toxicity.
Vinorelbine and capecitabine are both active in breast cancer with moderate toxicity.
Bioassays (Hemolytic, brine shrimp and Ames test) revealed that the R. communis methanolic extracts have compounds responsible for mild to moderate to moderate toxicity.
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