Sentence examples for moderate renal function from inspiring English sources

Its pharmacokinetics and pharmacodynamics are not significantly altered in patients with moderate renal function or hepatic impairment.

She was known with a chronic moderate renal function impairment as a result of a double-sided nephrolithotomy at age 40.

In patients with moderate renal function impairment, the mean eGFR change from baseline was −1.62 and −1.80 mL/min/1.73 m in patients on vildagliptin and placebo, respectively.

This finding may turn useful particularly in the era of NOACs which are excreted, even if to a different degree by the kidney, and whose dosage requires to be tailored in case of patients with AF with moderate renal function.

Dose reductions were necessary in 10 patients, due to hand foot syndrome (n=3), diarrhoea (n=2), and in one patient each due to haematological reasons, weight loss, moderate renal function impairment, vomiting and symptoms of vertebral fracture with spinal cord compression (the latter were signs of tumour progression).

The incidence of any investigator-reported hypoglycaemia with linagliptin was higher in subjects with RI: 11.1, 11.9 and 15.9% in the normal, mild and moderate renal function categories, respectively; with placebo, these rates were 6.9, 9.0 and 12.0%, respectively (Table 3).

Schumacher et al concluded that at all doses studied febuxostat more effectively lowered and maintained serum urate levels <0.36 mmol/L than did allopurinol or placebo in subjects with hyperuricemia and gout, including in those with mild to moderate impaired renal function.

In the present experimental setup, we investigated the functional outcome following a severe ischemia time of 40 min. In scid beige mice, this extent of injury resulted in a comparatively moderate reduction of renal function.

MRL/lpr mice showed moderate proteinuria and renal function defects at 20 weeks.

When there was a moderate impairment of renal function, the AUC0−24 increased by about 1.3-fold compared to normal function.

In the study group we have found moderate reduction of renal function and discreetly elevated values of IMT and LVMI.