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Hence, adjusting the renal clearance of urate according to creatinine clearance (that is, calculating the FCU), means that FCU is approximately independent of glomerular kidney function for subjects with reasonable renal function.
In most studies, either the requirement for entry was reasonable renal function (creatinine clearance greater than 30 ml/minute [ 44] or 20 ml/minute [ 39]) or renal function was relatively unimpaired (mean creatinine clearance was 80 ml/minute [ 43]).
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Treatment with low molecular weight heparin (enoxaparin 40 mg daily) is a reasonable alternative if renal function is normal (Class IIB, Level of Evidence C).
Serum creatinine may, therefore, be a reasonable estimate of renal function at one point in time and a strong risk marker, but with significant shortcomings for accurate assessment of GFR.
An intravenous volume load is a widely accepted prophylactic measure and possibly a reasonable intervention to prevent deterioration of renal function.
Patient selection criteria include demonstration of superior radiopharmaceutical uptake at all known tumour sites on diagnostic imaging by comparison with normal tissues, reasonable bone marrow reserve, and adequate renal function.
The current standard therapy in the United Kingdom for patients with gastro-oesophageal cancer, adequate renal function and a reasonable performance status is ECF (epirubicin, cisplatin and continuous infusional fluorouracil), the best results being noted in patients with nodal and hepatic metastases (Webb et al, 1997).
It might seem a reasonable possibility that the poorer the baseline renal function, the longer the retention of CM.
The authors concluded that serum uric acid levels might be reasonable to determine which patients were at higher risk for developing worsening renal function in the near future [ 16].
Reasonable agreement of mGFR and eGFR values was observed in patients with poor renal function [GFR below 60 (ml/min)/1.73 m].
Of 39 osmolarity equations, 5 showed reasonable agreement with directly measured osmolality and 3 had good predictive accuracy in subgroups with diabetes and poor renal function.
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