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However, normalization is frequently associated with an improvement of symptoms or a moderate clinical response.
Six patients fulfilled the EULAR criteria for moderate clinical response, and another 19 for good clinical response.
Six of 35 patients fulfilled the European League Against Rheumatism criteria for moderate clinical response, and 19 others for good clinical response.
According to the EULAR criteria, a good or moderate clinical response was achieved in 63.5% of patients at T3 and in 56.8% of patients at T6 (Table 2).
None of the patients with a drop of any Ig isotype below the lower normal limit developed clinical symptoms of immunodeficiency, but seven of these patients experienced good clinical response and one patient experienced moderate clinical response.
In our study using preoperative chemotherapy alone with radiation applied intra- and postoperatively, we observed a moderate clinical response rate, which was in the range reported by other groups using preoperative chemotherapy, chemo-hyperthermia or chemoradiation 11-299%) [ 22, 50, 53].
Similar(53)
Cows had a moderate systemic clinical response to both challenges, but after the second challenge local signs were significantly milder and disappeared faster.
Interestingly, all patients carrying the IL-6 -174CC genotype showed a moderate or good clinical response according to the EULAR criteria after six months of follow-up.
Grade 2 No change – no increase or decrease in pain intensity or frequency Grade 3 Moderate improvement – partial clinical response with definite improvement in pain, but not meeting the criteria for a Grade 4 response.
In contrast, the absolute number of switched MemB at month 6 (P = 0.049), month 9 (P = 0.045), and month 12 (P = 0.003) was significantly higher in patients with no or moderate time-matched clinical response to RTX than in good responders.
Controlled clinical trials demonstrated that infliximab is characterized by a high degree of clinical response in moderate to severe plaque psoriasis.
Related(20)
reasonable clinical response
slow clinical response
modest clinical response
mild clinical response
milder clinical response
moderate immune response
moderate clinical deterioration
moderate clinical mastitis
moderate clinical risk
moderate clinical attack
moderate clinical validity
moderate affective response
moderate clinical malnutrition
moderate clinical heterogeneity
moderate clinical effect
moderate clinical significance
moderate clinical importance
moderate clinical benefit
moderate clinical depression
moderate clinical confidence
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