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One promising approach to modeling heterogeneous cell responses is to run 'populations' of models, to recapitulate the behavior of populations of cells.
Bioengineered approaches allow cell biologists to develop sophisticated experimentally and physiologically relevant cancer models to recapitulate the complexity of the disease seen in patients.
"There is a need to develop better animal models, to recapitulate and predict effects of agents on the molecular pathology of the disease process, and also to develop better imaging and biomarker technologies to assess, as early and precisely as possible, drug effects in clinical studies," he says.
Recently, questions have been raised regarding the ability of animal models to recapitulate human disease at the molecular level.
Rats are the most favourite wound healing animal models to recapitulate human physiology and forecast therapeutic outcomes.
Three-dimensional spheroids are therefore considered valid models to recapitulate features of tumor microregions, intervascular domains or micrometastases [ 10, 12].
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We use our model to recapitulate the dynamics of the parallel remodeling processes that occur in close proximity across a typical eukaryotic genome.
In this study, thus, we developed a new in vitro tumor model to recapitulate the tumor microenvironment determining the transport around tumors.
We subsequently developed a three-dimensional model to recapitulate the process of EMT with these cell lines.
However, owing to significant challenges regarding the in vivo system, such as the complex cellular environment and potential problems with embryo manipulation, it is desirable to generate embryonic stem (ES) cells that are capable of overcoming these aforementioned limitations in order to provide a potential in vitro model to recapitulate the developmental processes in vivo.
We established an OS model to recapitulate some of the effects of Dkk-1 and OS in vivo.
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