Sentence examples for systems to recapitulate from inspiring English sources

While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex 3D organization of PDA.

The low efficiency of CCC DNA formation in tissue culture cells and the lack of permissive in vitro systems to recapitulate the conversion of RC to CCC DNA, hampered efforts to investigate the first step critical in hepadnaviral DNA synthesis.

Moreover, these results demonstrate the ability of iPSC-based cellular systems to recapitulate PD-related pathology and to model a monogenic form of PD.

Unfortunately, the lack of culture systems to recapitulate spermiogenesis has precluded in vitro studies (i.e., use of transfections or siRNA knockdowns), necessitating the use of mouse knockout and conditional mutants to understand the roles of genes expressed in spermatogenesis.

RIP1 is quite challenging in this regard, as it has independent kinase and scaffolding functions, limiting the utility of knockdown and knockout systems to recapitulate the effects of inhibitors.

We therefore designed an in vitro system to recapitulate the cellular events of M. marinum internalization, apoptosis of infected macrophages, and phagocytosis by secondary uninfected macrophages.

Furthermore, CPVT-CMs also developed DADs and triggered activity (TA) when paced at 0.5 Hz (12%, 2 out of 16, Figure 4a), confirming the ability of our model system to recapitulate the disease phenotype in vitro.

Vesicular stomatitis viruses bearing filovirus GP proteins (VSV pseudotypes) provide a highly validated surrogate system to recapitulate filovirus entry under biosafety level 2 containment (Takada et al., 1997; Jangra et al., 2015).

To further explore the thermodynamic role of major groove cations in DNA stability, we created a model system to recapitulate the observed locations of major groove monovalent cations by synthesizing 7-aminomethyl-7-deazaguanine (7amG) and incorporating it into sites with different flanking sequences.

Because early embryonic loss accounts for the majority of cow infertility [ 7], we have previously created an in vitro fertilization (IVF) system to recapitulate the early development of cattle and allow systematic investigations of abnormities during the very early stages of development [ 8].

In summary, several factors appear implicated in the neurodegenerative phenotype of A-T, but which of them are most crucial is still debated, primarily because of the unavailability of human model systems able to recapitulate the neurological disease in vitro.