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Many mouse DS models show reduced hippocampal LTP (Box 1).

Some mice show increased synaptic density in specific brain regions, while most models show reduced synaptic density.

All FA mouse models show reduced fertility, and cells derived from all mutant mice are sensitive to ICL-inducing agents – the characteristic cellular phenotype of FA.

Although the TgPWS/TgAS mouse models show reduced expression of several other genes, including Siglec-H, Luzp2 and Chrna7, as compared to the human PWS and AS class I deletions, none of these additional genes are likely to contribute to the TgPWS and TgAS phenotypes.

These models show reduced tumor burden and prolonged lifespan as compared to conventional GEMMs, and are therefore more suitable to study tumor initiation, progression and therapy response [ 7].

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Both adjustment models showed reduced estimated effects for the 12 drugs relative to the placebo as compared with NMA of published data.

Indeed, data from a UUO model showed reduced fibrosis in Mmp9−/− mice (Wang et al., 2010).

Moreover, a second short-lived hyper-p53 mouse model showed reduced IIS, at least in the mammary gland [ 18].

This is consistent with the results obtained in the lipopolysaccharide (LPS -induced caLPS -induced showing reducalvariaoclast activity in vivo.

A Norwegian study using a linear regression model showed reduced length of stay with increased long-term care.

Consistently, the Drosophila CG disease model showed reduced activity and impaired movement coordination, which were fully rescued by transgenic expression of human GALT, demonstrating full functional conservation.

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