In summary, M-T1 and M3, viral CMPs known to target chemokine-receptor interactions, inhibited plaque growth in WT aortic transplant models, but displayed reduced activity in Ccr2−/− donor to WT C57Bl/6 recipient mouse aortic transplants.
Both the MIA and MNX models of OA displayed reduced ipsilateral weight bearing and hindpaw mechanical withdrawal thresholds, mild synovitis and increased TrkA expression in DRG.
The HD model, R6/2 transgenic strain displayed reduced expression of Per2 and blunted oscillation of Bmal1 in the SCN, as well reduced in motor cortex and striatum.
Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout mice showed increased anxiety-like behaviour, compared to wildtype controls.
Indeed, in a small mammal model, nephrin-/ murine myoblasts displayed reduced fusion capabilities during in vitro myogenesis [ 36].
The Df(17 1Yey/+ monosomic mouse model, encompassing the Abcg1 Rpr1b interval, displayed reduced swimming speed in the Morris water maze and decreased freezing time in the contextual fear-conditioning paradigm (Yu et al. 2010a).
In an experimental model of starvation, fasted wild-type mice displayed reduced villi and lower intestinal weight compared with Lgals1−/− mutant mice, an effect reflected by changes in the frequency of enterocyte apoptosis.
While many mutants displayed reduced activity, our findings do not match the predictions of this model.
Interestingly, DKK2 transgenic mice displayed reduced tuft formation (66%% of wild-type levels) in the OIR model as DKK1 Tg mice (Fig. 7a, d).
miRNAs in bold were validated by Northern blot analysis * Summarized from [ 41- 43] MiR-143 and miR-145 consistently displayed reduced expression levels in CRC clinical samples and were undetectable in CRC cell line models.
