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The extent to which these models recapitulate the human disease remains debatable.
Treatment options are limited, and few experimental models recapitulate the key features of the condition.
slc4a11-null-mouse models recapitulate the CHED disease phenotype, thus establishing a functional role for SLC4A11 in CHED.
In terms of preclinical studies, the assumption that childhood cancer in vivo models recapitulate the actual disease has not always proved correct [225], [240], [241], [242].
Although ESC differentiation experimental models recapitulate the successive steps from pluripotency to well-differentiated cells, the molecular mechanisms underlying these processes are poorly understood.
Somatic mouse cancer models recapitulate the somatic nature of cancer progression and bypass the embryonic lethality caused by whole-body knockout of certain genes.
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The models recapitulated the effect of high doses of PKC and CDK4 inhibitors required to decrease cell viability.
In general, COX-2 expression in the neu-induced retroviral mammary carcinogenesis rat models recapitulates the expression patterns observed in women.
Gene therapy is under study for a variety of diseases, mostly in pre-clinical studies performed in animal models recapitulating the LSDs, phenotypes.
Primary cell line models recapitulated the mutation profiles of the original primary tumours and provide an invaluable resource for experimental cancer therapeutics.
DOI: http://dx.doi.org/10.7554/eLife.03069.009 Can this tethered delivery model recapitulate the catalyst-like action of these polymerases?
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