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In essentially all models, mice with prostate-specific Pten inactivation showed development of hyperplasia, mPIN lesions and ultimately prostate cancer [12] [15].

RESULTS: To explore Glis3's role in adults, we generated two independent mouse models: mice with haploinsufficiency of Glis3 (Glis3+/−) and inducible pancreatic beta cell-specific Glis3 deficiency (Glis3 fl/fl /Pdx1Cre ERT+ ).

In mouse models, mice with specific defects in folate transport had higher rates of neural tube defects after in utero arsenic exposure than wild-type mice similarly exposed [ 5, 11].

In all these three models, mice with liver-specific activation of Ikk2 were examined at around 12 weeks of age, and thus the differences in hepatic gene expression and pathophysiology among these mouse models are unlikely due to differences in age.

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Both of them displayed specific labeling of Aβ plaques in the brain sections of AD model mice with low background.

In the present study, we induced clinical diabetes in animal model (mice) with STZ administration (240 mg/kg) during their adult life before pregnancy.

The in vivo study of this TiO2 Sil TSPP conjugate on an animal model (mice with implanted cancer cells under skin) showed that the conjugate inhibited tumor growth after laser irradiation (Fig. 8).

We labeled HaloTag with near-infrared fluorescence (NIRF) dyes and injected the resultant PTD3-ODD-HaloTag-ligand-NIRF dye (POH-N) into model mice with cancers, resulting in successful monitoring HIF-1-active [HIF ] regions in the model mice.

The skin thickness of the model mice with transferred Ni-BMDCs-stimulated T cells was significantly increased compared with that of mice with transferred nonstimulated T cells (Figure 4B).

In this study, we describe for the first time gene expression analysis on fetal tissue of DS model mice with the ultimate goal to identify potential biomarkers applicable for prenatal serum screening.

Model mice with 129 repeats within an introduced ATN-1 transgene exhibit a severe phenotype reminiscent of juvenile onset DRPLA.

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