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The development of MCL models has facilitated quantification of drug penetration through solid tissue.
The conflation of generation technologies with large network models has facilitated cleavage within groups which might be viewed as having both "conservative" and "progressive" tendencies.
The detailed information provided by the use of computational fluid dynamic models has facilitated unique opportunities to investigate alternative system designs, without the need for expensive and time consuming experiments.
Indeed, the use of codon models has facilitated the identification of selection occurring at sites [4], [5] and along lineages [6], [7].
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Both derived computational models have facilitated the identification of the structural elements of the ligands that are key to high 5-HT4R affinity.
Animal models have facilitated the investigation of the mechanisms of several diseases.
Despite some discordant results, these in vitro and in vivo models have facilitated the characterization of IBC.
More importantly, the models have facilitated the identification of the conditions under which these dynamics may realise, which would have been infeasible if such models are not used.
Yet, in spite of the advances these models have facilitated, numerous findings have also been unsuccessfully translated to humans, as evidenced by the failure of many clinical trials.
Finally, we review how organotypic models have facilitated the study of several key pathways in cancer development and invasion, and speculate on the exciting future roles for these models in cancer research.
108 Mouse models have facilitated the progress in understanding the molecular pathogenesis of AS. 109 The Ube3a knockout mouse, generated with target disruption of Ube3a on the maternal chromosome 7, nicely recapitulates the human disorder.
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