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The next level of the hierarchy comprised studies that used models for validation, including animal models [11 13] and mechanical experiments.
We selected a sample of eight gene models for validation by RT-PCR: one with two 3'UTR introns, two with introns in the 5' UTR, and five with introns within the coding region.
Transcript models for validation were chosen among low FPKM ranges, 0.86 111.56, where 18 transcripts corresponded to previously known genes in the reference genome and 38 corresponded to transcripts that had not been previously described.
Following the optical imaging protocol, the samples were imaged on a microCT platform (VivaCT40, Scanco) to obtain a volumetric map of the models for validation of the tomographic localization using this method.
In a recently published review about the future of simulation technologies for complex cardiovascular procedures references were made to several VR validation studies in endovascular procedures; however all of those studies used animal models for validation [ 19] and to our knowledge, no study has evaluated the transfer of CA skills from VR to OR in humans.
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As time progressed in the field of validity studies, the construct validity approach was widely accepted as a general model for validation (Anastasi 1986; Embretson 1983; Guion 1977; Messick 1980 , 1988 , 1989
An experimental programme was conducted alongside the modelling, for validation purposes.
Using in vivo study, we performed a rabbit hypertrophic scar model for validation of CO2 fractional laser protocol.
Figure 6 Measured BHE thermal load set as a boundary condition to the model for validation purpose.
The results obtained with both models have been compared with the predictions of the detailed model for validation purposes.
The current study presents a model for validation of a battery of aptitude tests for psychologists using the criterion method of behavioural anchors based on core competences.
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