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Goursaud, A. S. and Bachevalier, J. (2007) Animal models for autism.
Hoffman-La Hoffman-La Rochend other Pfizerrs and testing the effects otherugs on behaviors in mouse models for autism.
For example, mice treated with valproic acid on gestational day 11 are well-established animal models for autism.
Other mouse models for autism have reported a very different pattern in terms of the structural property of calls.
Several kinds of animal models for autism have been reported (Moy et al., 2006; Murcia et al., 2005; Persico and Bourgeron, 2006).
The CHARGE study also benefits from CCEH hypothesis-driven experimental research on animal models for autism in mice and non-human primates and in vitro investigations of immune and neurogenic cells aimed at uncovering molecular mechanisms.
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Our findings are consistent with the hypothesis that GNB1L mutations are risk factors in a multigenic threshold model for autism.
This chromosome-engineered mouse model for autism seems to replicate various aspects of human autistic phenotypes and validates the relevance of the human chromosome abnormality.
Collectively, the potential involvement of these specific genes that are associated with neurological function and disease and their presence in pathways regulated by inflammatory mediators lend further support to the neural inflammation model for autism [ 34], which may be also manifested by immune dysfunctions commonly observed in autism [ 43].
Thus the Ms2Yah mice might represent a model for autism with several functions affected in the brain without any notable cellular defects, but with changes in the expression of genes involved in the postsynaptic functions without any stereotypies detected so far.
In conclusion, the data indicate that Syns could represent a common genetic basis for epilepsy and ASD and that Syn KO mice represent an interesting animal model for autism-like phenotypes.
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