Sentence examples for modeling and mutational from inspiring English sources

Homology modeling and mutational analysis demonstrated a single mutation in human FFA2 of C4.57G resulted in a human FFA2 receptor with ligand selectivity similar to the bovine receptor.

Based on homology modeling and mutational analysis, we have identified amino acid residues that are critical for substrate binding.

Furthermore, we observed homodimerization of the RIPK2 CARD domains and, based on molecular modeling and mutational analysis, identified positions in the CARD1 domain of NOD2 that are essential to mediate interaction with RIPK2.

Computational modeling and mutational analysis of the TLR10/TLR2 complex [ 18] suggested the presence of a TLR2 dimer interface and the lipopeptide-binding channel homologous to that found in TLR1.

We used homology modeling and mutational analysis of base excision and DNA binding to identify residues important for recognition of 5mC within the context of DNA and inside the enzyme active site.

The wild-type and inherited mutations of β-mannosidase were studied across four different species, human, cow, goat and mouse employing a previously demonstrated comprehensive homology modeling and mutational mapping technique, which reveals a correlation between the variation of genotype and the severity of phenotype in β-mannosidosis.

Sequencing of the UV-induced lacZ′ mutants provided mutation spectra and mutational hot spots for the various UV regions.

Structural modeling and energetic analysis of the mutational hotspots have suggested a common molecular mechanism of kinase activation by cancer mutations, and have allowed to reconcile the experimental data.

Structural modeling and energetic analysis of the mutational hotspots have also suggested a common molecular mechanism of kinase activation by cancer mutations, which may be determined by a combined effect of the partial destabilization of the inactive state and a concomitant stabilization of the active-like form of the enzyme.

Furthermore, structural modeling and energetic analysis of kinase cancer mutations, which constitute the largest mutational hotspot, have provided useful insights into a common mechanism of kinase activation.

Pocket characterization, enzyme structural stability and mutational effect were analyzed in silico.