Sentence examples for design and mutational from inspiring English sources

Riley, T. P. et al. A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.

Generally, inconsistent amplification or amplification failure of EST-SSR loci may arise as a result of factors such as the presence of introns that are too large for efficient amplification, the use of poor quality sequences for primer design, and mutational substitutions, insertions or deletions within the priming site [ 60].

Here, we examine the influence of experimental design and mutational properties on the mapping success of BSA-seq when the density of segregating sites is low, with the goal of providing a general framework for large-scale mapping of small effect mutations after a mutagenesis screen.

Different models such as selection for economy model, genomic design model, and mutational bias hypotheses have been proposed to explain such observation.

In order to explain the relationship between gene characteristics and gene expression, different models, such as selection for economy model, genomic design model and mutational bias hypotheses have been proposed.

The experimental structure is significantly different from an earlier homology model, which could have led to improper estimation of receptor interaction surfaces and design of mutational experiments.

This comparative review of antifolate binding in diverse species provides new insights into the relationship between antifolate design and the development of mutational resistance.

In this paper we describe an efficient and inexpensive single-tube two-step megaprimer-based PCR mutagenesis strategy (Fig. 1) that by-passes the cumbersome and time-consuming gel purification step, does not require additional expensive DNA-modifying enzyme treatments, is not restrictive in primer design, and has a high mutational efficiency.

RNAexinv focused on the design of sequences with enhanced thermodynamical and mutational robustness (Avihoo et al., 2011), while Frnakenstein enables to design RNA with multiple target structures (Lyngsø et al., 2012).

PB, MB: designed the study, analyzed clinical and mutational data and drafted the manuscript.

D.R. designed proteins and performed mutational and functional studies.