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Here, we summarize our current understanding of mutational patterns and mutational signatures in light of both the somatic cell paradigm of cancer research and the recent developments in the field of cancer genomics.
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The p53 plasmids can be rescued from the yeast strain and sequenced so that mutational patterns and the mutational spectra can be ascertained, Figure 12.
The several hundreds to tens of thousands of somatic mutations in each cancer, therefore, potentially allow much greater resolution of mutational patterns and insights into underlying mutational processes.
No patients experienced recurrence or distant metastasis of the PTC, regardless of the X-chromosome inactivation pattern and BRAF mutational status.
In addition, more cases with multicentric PTCs can be included in the residual cases with those having concordant X-chromosome inactivation pattern and BRAF mutational status.
We identified 1,796 clustered DNMs (cDNMs) within whole-genome-sequencing data from 1,291 parent offspring trios to investigate their patterns and infer a mutational mechanism.
We examined X-chromosome inactivation patterns and the BRAF mutational status of 32 PTCs from 14 patients using HUMARA and AS-PCR, respectively.
To investigate the correlation between drug treatment and mutational patterns, we compiled six datasets of sequences, summarized in Table 1.
Here, we carried out the first comparative study of substitution rates and mutational patterns in a sizable fraction of the conifer gene set - or that of any gymnosperm.
The HBV genotype influences clinical outcomes, serum HBV DNA levels and mutational patterns in the pre-core and core promoter regions [ 14].
The results of that analysis suggested that there is a significant relationship between motif imperfection and mutational patterns in the microsatellite loci.
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