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In clinical trials, Ki-67 clone Mib-1 could be used in conjunction with the mitotic index to ensure correct tumour classification on the basis of proliferative potential.
At 3 days after docetaxel treatment, many cells were blocked in mitosis, increasing the mitotic index to 40, 29 and 56% in PAC120, HID25 and HID28, respectively.
Arsenite treatment delayed the peak in mitotic index to 6 hr after release from G2 phase in both p53 and p53 cells.
The in vitro micronucleus test however allows the parallel investigation of the nuclear division index or the mitotic index to monitor cytotoxicity, and evaluation of binucleated (vital) cells can avoid the inclusion of damaged cells (Fenech 1993).
Immunofluorescence microscopy showed an increase in the mitotic index to 26.2% upon C13orf3 depletion (3.6% for mock control), of which 80.5% of the cells were arrested in a metaphase-like state (36.1% for mock control).
One might expect mitotic index to correlate well with prognosis as faster growing tumours should logically lead to shorter survival, and indeed this has been found to be the case in some CNS tumour types [ 44].
Similar(51)
Degradation of either hY1 or hY3 RNA (or both) is feasible in human cells by transfection of specific siRNAs, leading to a significant reduction of the proportion of replicating cells in the treated population (S phase index), to a reduction of the mitotic index and to a cytostatic inhibition of cell proliferation.
Moreover, co-depletion of cenp-ana and cenp-meta in Drosophila S2 cells by RNAi yield to a phenotype and a mitotic index identical to the single RNAi depletion of cenp-meta (Goshima and Vale, 2003) strongly suggesting that Cenp-meta is likely to be the Drosophila homolog of vertebrate Cenp-E.
Histological examination showed morphological characteristics similar to the primary tumor; however, the mitotic index (up to 40 mitoses within 10 HPF) and Ki-67 labeling index (40%) were higher than those of the primary counterpart.
This mitotic index increased to 0.63% by nine hours post E. coli infection and then dropped to around 0.1% by 12 and 24 hours post-infection.
The mitotic index started to increase again 24 hr after release from G2 phase, indicating that the cells had started to cycle again.
Related(20)
mitotic localization to
mitotic sensitivity to
mitotic cytokinesis to
mitotic division to
mitotic stimulus to
mitotic progression to
mitotic slippage to
mitotic collapse to
mitotic proliferation to
mitotic response to
mitotic exit to
mitotic activity to
mitotic entry to
mitotic spindle to
mitotic commitment to
mitotic recombination to
mitotic growth to
mitotic selection to
mitotic checkpoint to
mitotic stability to
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