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Exact(6)
Blacks (adjusted odds ratio [AOR], 2.38; 95% confidence interval [CI], 2.22-2.57) and Hispanics (1.17, 1.07-1.28) manifexcessexcess potential suicide misclassification relative to Whites.
Our primary exposure metric, distance from the highway, likely introduced exposure misclassification relative to what might be seen with individually-assigned exposures to UFP.
This possibility is standard to environmental epidemiology studies, and our use of sophisticated, spatially and temporally resolved models to estimate individualized residential pollutant exposures has likely reduced misclassification relative to fixed monitoring studies.
This cut-off was chosen using the study data to minimize misclassification relative to the use of the full PCL scale with a conventional diagnostic cut-off of 50 or higher [ 31].
An additional strength is that we measured individual noise exposure, which may have substantially reduced exposure misclassification relative to previous studies that estimated noise exposure based on noise mapping.
On the one hand, our null findings could have been the consequence of substantial misclassification relative to exposure in the etiologically critical time windows: measurements in plasma samples collected at least a year and potentially as much as five years after the key events in neurodevelopment may have been poor approximations of the relevant prenatal or early postnatal exposures.
Similar(54)
Therefore, exposure misclassification should be reduced relative to other cohort studies that have assigned exposures to place of residence.
Misclassification of this exposure (relative to the timing of the blood draw) was possible because these products tend to be used intermittently and because some may not contain thimerosal.
For large datasets such as the ones used in this study, sampling error may be small relative to misclassification error, and narrow 95% confidence intervals may give a false sense of certainty about estimated prevalence rates.
It is unclear how influenza test misclassification biases test-negative VE estimates relative to VE estimates from traditional cohort or case-control studies.
We quantified resulting patterns of misclassification and discussed the relative value of each relative to ongoing development of prognostic biomarkers.
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Justyna Jupowicz-Kozak
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