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The lateral views (Figs. 4I'-L') show more pronounced etsrp cell migration defects in VEGF GOF embryos.

Mutations in mbc and elmo result in border cell migration defects in the ovary and myoblast fusion defects in the embryo [25], [26], [27].

Largemyd mice bear an intragenic deletion in the Large gene [41], and exhibit neuronal migration defects in the brain and eye abnormalities similar to CMDs in humans [44].

Mutations that diminish the function of the extracellular matrix receptor Dystroglycan (DG) result in muscular dystrophies, with associated neuronal migration defects in the brain and mental retardation e.g. Muscle Eye Brain Disease.

Cell migration is also essential in brain development, and the migration defects in CEDNIK derived fibroblasts could explain the cerebral dysgenesis in the patients, manifested by polymicrogyria (excessive number of small convolutions (gyri) on the surface of the brain) and pachygyria (thick convolutions of the cerebral cortex) which are both disorders of neuronal migration [46].

We confirmed the migration defects in progeny pgc mutant mothers.

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Similar(26)

The electroporated cells (GFP+) migrated to layers 2/3 without obvious migration defect in all experimental conditions.

Both trol germline clones and trol RNAi in the CVM cells resulted in a migration defect in which cells from each of the two migrating collectives merge at the midline (compare Figure 7B with Figure 7, C and D arrows), similar to the phenotype caused by removing FGF signaling (Kadam et al. 2012).

Transgenic flies created using these constructs were assayed for their ability to maternally rescue the tre1sctt germ cell migration defect in the context of developing embryos.

No apparent migration defect in Gsk3:Dlx5/6 mice.

Experiments in this study explore the basis of the neuronal migration defect in the fh131 mutant.

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