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Furthermore, pharmacological activation of the C3a and the C5a receptors prevented neuronal migration deficits in case of C3 or Masp2 knockdown and exhibited complete restoration of the position of neurons in C3 knockout brains, suggesting that a single intervention may be sufficient to ameliorate migration phenotypes.
A potential involvement of neuronal migration deficits in RD aetiology represents a longstanding hypothesis of the field (see Galaburda & Cestnick 2003).
Since we observed Purkinje cell migration deficits in Foxc1 −/− mutants, we assessed if SDF1α has yet another role, acting as a pial surface chemoattractant to differentiating ventricular zone derived cells.
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Finally, we have employed BrdU in birthdating studies to demonstrate an in vivo neuronal migration deficit in Jna/+ mice.
Zhou, J. et al. Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle.
Partial knockouts have shown that under-expressing reelin during rodents' development leads to neuronal migration deficits [51] and to shorter hippocampal dendrites in adulthood [49].
Neuronal migration deficits should be considered as one of the underlying pathologies in ASD11.
Strikingly, the majority of cells transfected with either RHEBp.P37L or RHEBp.S68P remained in the subplate (SP), indicating more severe migration deficits compared to RHEB-WT overexpression (Fig. 4a).
Neuronal migration deficits are often linked with seizures and ID47.
Figure 3: cleavageage products can rescue upstream migration deficits.
Moon, U. Y. et al. Impaired reelin-dab1 signaling contributes to neuronal migration deficits of tuberous sclerosis complex.
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