Sentence examples for movement defects in from inspiring English sources

To investigate the cellular mechanisms that underlie the cell movement defects in zdia2 morphants, we used time-lapse CCD camera recording to observe cell behavior and protrusive activities in both stdMO and zdia2 morphants.

In vivo, FGFR and MEK inhibitors can prevent cell movement defects in BRAF CFC- and MEK CFC-expressing zebrafish embryos (Anastasaki et al., 2009).

We show that the expression of both BRAF and MEK kinase-activating and kinase-impaired CFC and melanoma alleles cause similar phenotypes with significant cell movement defects in early embryogenesis.

To quantify the movement defect in morphants, we measured spontaneous coiling.

The highly specific and clinically active MEK inhibitor, CI-1040 was able to suppress the cell movement defect in early embryogenesis caused by CFC kinase mutations.

Third, we tested whether low-level galactose exposure in development, and the elevated gal-1P values that result, would impact the severity of the movement defect in GALT-null adult flies.

Whether the sluggish movement defect seen in adult apl-1 knock-down worms is due to the molting defect, starvation or a neurotransmission defect remains to be seen.

Additionally, because Smed-tph is required for serotonin biosynthesis [ 61– 63], the Smed-tph RNAi movement defect is in line with previous observations that the coordinated wave-like motion of the ventral cilia of planarians is controlled by serotonin [ 9, 64].

The RNAi knockdown line of LIN-49 shows post-embryonic growth defects, sterile progeny and uncoordinated movement defects, phenotypes which are also observed in a naturally occurring mutant in which the sixteenth ligand (20 ligands total) of the PZPM has been changed from Cys to Ser, presumably disrupting the motif [ 38].

However, morpholino-mediated knockdown of CPA6 did not result in any visible defects in the trajectory of the VIth nerve nor in any behavioral eye movement defects specific to either the medial or lateral rectus muscle.

Expression of BRAF CFC and MEK CFC mutant alleles in zebrafish embryos causes cell movement defects during early development, indicative of activated FGF-MAPK signalling in gastrulation cell movements (convergence-extension) (Krens et al., 2008).