Sentence examples for might predict sensitivity from inspiring English sources

Since SCCHN has emerged as an extremely important clinical target for oncolytic reovirus therapy, we undertook a detailed analysis of the factors that might predict sensitivity to treatment in SCCHN with a view to defining predictive biomarkers for testing in future clinical studies.

We wondered if HDAC6 expression in the different cell lines might predict sensitivity to C1A.

We tested whether this signature might predict sensitivity to EGFR inhibition in other epithelial tumour types.

We proposed that this might also be the case for inhibitors of alternative kinases involved in the cell cycle and so might predict sensitivity to inhibition of Chk1 and Aurora A by 1.

The present study showed for the first time that, in addition to clinical parameters, the expression of the mitochondrial gene RNR1 in tumour tissue might predict sensitivity of ovarian carcinomas to chemotherapy.

We hypothesised that this BRCA1-likeCGH classifier could also detect loss of function of BRCA1 due to other causes besides mutations and, consequently, might predict sensitivity to DSB-inducing agents.

These results suggest that EB1 expression in breast tumor tissues might predict tumor sensitivity to paclitaxel-based treatment.

We performed a genome-wide siRNA screen for enhancers and suppressors of a Kinesin-5 inhibitor in human cells to elucidate cellular responses, and thus identify factors that might predict drug sensitivity in cancers.

To determine whether inhibition of cytoskeletal regulatory proteins might predict dasatinib-sensitivity, cells were treated with dasatinib and protein lysates probed for phosphorylation of the cytoskeletal regulatory proteins focal adhesion kinase (FAK), p130CAS, and CrkL, each of which are substrates of Src family kinases (Gonzalez et al, 2006).

These oncogenic lesions predict sensitivity to specific inhibitors.

On the basis of this, one might predict that this increased sensitivity of mitochondrial respiration to inhibition by NO would lead to increased local O2 partial pressure and concomitantly decreased hypoxia due to inhibition of mitochondrial O2 consumption.