Sentence examples for might confer sensitivity from inspiring English sources

Accordingly, we reevaluated the genomic attributes of the SLC6A3 gene that might confer sensitivity to regulation, hypothesizing that its unique genomic characteristics might facilitate highly dynamic, region-specific DAT expression, so enabling multiple regulatory modes.

BRCA1 mutations and other associated molecular traits might confer sensitivity to specific therapeutic agents [ 7– 10].

Whether PIK3CA or AKT1/2/3 amplifications might confer sensitivity to PI3K inhibition in HGSOC has never been investigated.

Although the reason why the single bortezomib regimen is not significantly active in clinical trials might be explained by the possibility of the activation of multiple drug resistance pathways in heavily pretreated populations, particularly those previously exposed to anthracycline [ 16], alternative mechanisms might also confer sensitivity to bortezomib in patients with breast cancers.

On the other hand, many other reported effects of estrogen in hippocampal area CA1 might confer increased sensitivity to ischemia, either by modulating the excitatory effects of glutamate or by modifying the inhibitory effects of GABA.

Although mouse Slo3 is insensitive to intracellular Ca2+ (Schreiber et al., 1998), we wondered whether the auxiliary subunit LRRC52 (Yang et al., 2011) might confer Ca2+ sensitivity on Slo3 channels.

PI3KCA mutations are common in breast cancer and these mutations might confer the sensitivity to inhibitors as anti-EGFR or anti-AKT1, although the relationship of PI3KCA mutations and prognosis of breast cancer patients has not been unequivocally reported.

This notion is also supported by the results of Li et al. [ 49] which suggest that EGFR is involved in constitutive JNK activation in diffuse gliomas and that the ability to inhibit JNK activation might confer increased sensitivity to therapeutic modalities targeting this pathway.

Based on these data, it is possible that individuals carry Top2 variants composed of defective monomers, which might confer different sensitivities to inhibitors and affect treatment outcomes.

Therefore, we hypothesized that salinomycin might induce less autophagy in which CDH1 expression was inhibited and confer sensitivity to cell death.

Herein, we deployed a shRNA screen of 1,000 genes in multiple ALK-inhibitor-resistant patient-derived cells (PDCs) to discover those that confer sensitivity to ALK inhibition.