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This possibility suggested that 3AB might increase expression and reduce variegation both for reporters with an insulated enhancer and reporters with a mutant enhancer.

Since it was previously reported that immune stimulation might increase expression levels of PrPC on blood cells [54], we further analyzed PrP expression and cellular blood composition by flow cytometry analysis.

We found that such molecules were secreted at very low levels, and therefore explored how select mutations might increase expression.

One transcription regulatory role of tissue-specific 5hmC at certain intragenic or intergenic regions in specific tissues might be to serve as a long-lived intermediate in DNA demethylation creating DNA regions poised for upregulatory demethylation, which might increase expression beyond a low basal level.

Moreover, this study was performed on a part of the thoracic aorta that is exposed to high laminar shear stress, a condition that likely increases expression of Cx37 expression due to its effect on the transcription factor KLF2 [ 11] and that might increase expression of Cx40 due to the activation of Akt similar to the situation in arterioles [ 12].

LEP might increase expression of several enzymes involved in metabolism (e.g., aconitase 1 [ ACO1], carnitine O-octanoyltransferase [ CROT]) as well as decrease the expression of ESR1, which seems to have a central role in regulating expression of several other transcription factors (e.g., CTNN1B, FOXA1, MYC) as well as the prolactin receptor (PRLR) in PAR.

Similar(54)

These considerations suggested that treatment with 3AB might both increase expression and reduce variegation for reporter genes with an insulated enhancer.

Alternatively, gene amplification at target loci might selectively increase expression levels.

Weigel et al. (2000) reported that the 35S enhancer element might increase the expression of nearby genes without altering the original expression pattern.

Based on sequencing analysis and gene expression analysis, the nucleotide polymorphisms in γ-TMT3 promoter region might increase the expression level of γ-TMT3 in developing seeds of KAS, and subsequently associated with high α-tocopherol concentration in KAS seeds.

However, few factors have been identified that might increase EZH2 expression in prostate tumors [20], [21], [22], [23].

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