The differential effect of IL-2 and IL-15 on Myc expression suggests that the level of JAK kinase activity might determine the expression of Myc.
Therefore, within individual progenitors, stochastic bias or other external signals might determine gene expression.
Second, we also compared the different populations of ASC (MAPC versus MSC and ADSC) to determine expression profiles that might explain the differences observed between ASC, which were the second largest cause of variability in the data, as clearly indicated by the PCA.
Established breast cancer cell lines have been widely used to study signal transduction pathways, test new pharmaceuticals and determine expression profiles that might predict the metastatic capabilities of primary tumours.
Given our findings that the expression of vtrB is under control of VtrA (Fig. 3) and that vector-expressed vtrB could restore the defect in enterotoxicity of the WTΔvtrAΔvtrB strain (Fig. 5B), VtrB might determine this specific gene expression.
Although both the RasGEFs and RasGAPs proteins are needed to complete a full GTPase cycle and to allow for a switch between an inactive and active state of Ras, the activation state of these Ras proteins, but not the level of expression, might determine the cellular effects.
Moreover, recent studies have shown that endogenous levels of nodal expression might determine the capacity of specific hIPSC lines to differentiate into mesodermal derivatives [ 34].
The type and extent of these responses in protease expression might determine the degree of growth reduction in D. magna in the presence of cyanobacterial protease inhibitors.
Therefore, in 70% of gastric cancer cases with wild-type TP53, PICT1 expression status might determine the clinical outcome.
Taken together, a balance of nonself recognition by the PRG-1/piRNA pathway and self recognition by licensing factors such as the CSR-1 pathway might determine the outcome of gene expression in the germline.
